What Is Personalized Prostate Cancer Medicine?

Dr. Rana McKay is a medical oncologist at UC San Diego Health and an associate professor in the Department of Medicine at the UC San Diego School of Medicine. Learn more about Dr. McKay, here.

Katherine Banwell:

Dr. McKay, how would you define precision or personalized medicine, and how close are we getting to personalized medicine for advanced prostate cancer? 

Dr. Rana McKay:

Yeah. So, what I – how I define it is the right treatment for the right patient at the right time. It’s basically, you know, based off of somebody’s genomic profile of their tumor and ideally that genomic profiling is done close to the time that that treatment is being initiated.  

So, within six months or 12 months of somebody starting a given therapy, we understand the genetic make-up of the tumor. The tumor has, you know, for example, a BRCA1 alteration, and we know that olaparib is a drug that can be utilized and has demonstrated efficacy for people that have that mutation and then we would use that agent. So, it’s basically trying to personalize therapy based on the genomic information of that tumor.  

And, I think we are getting there. There are actually trials now that are being launched that are biomarker driven trials with bio-marker selected therapies for patients based on – off of not just DNA but also RNA to help with allocating a given therapy.