December 2022 Digital Health Roundup

December 2022 Digital Health Roundup

Scientists and engineers have teamed up to create new treatments to help fight cancer. These treatments sound like something out of a science fiction movie but are bringing us closer to ending cancer. Bacteriabots are nanobots used to destroy tumors and trigger the patient’s own immune response to fight their cancer. CRISPR is using CAR T-cells to create therapies for cancer patients that have run out of treatment options. Nanobubbles in combination with ultrasound waves are being used to kill cancer cells with positive results in early testing. As science and technology advance, it opens new options for cancer treatment.

The Army of ‘Bacteriabots’ That Could Combat Cancer Tumors

In this case, the bacteriabots colonized 3D tumor spheroids. They delivered chemotherapeutic molecules, demonstrating an innovative on-demand drug delivery method for cancer treatment reports InterestingEngineering.com . Biobots are time limited and programmed to self-destruct without leaving anything harmful behind. They are targeted for a particular task such as going to places of high acidity as in tumor tissue. Using bacteriabots helps to limit the unwanted side effects of treatment on healthy tissue, unlike the current treatments of chemotherapy and radiation. The use of bacteriabots is a non-invasive way to get into a closed environment like tissue and blood vessels. These biobots can also be used to trigger the patient’s own immune system. There are many things biobots could eventually be used for; treating other diseases and even repairing a torn ACL without surgery. Click to read the full story.

CRISPR Gene-Editing May Boost Cancer Immunotherapy, New Study Finds

CRISPR is developing cancer treatments using CAR T-cell therapies. These are called “living drugs” because they’re living cells of the immune system, taken from cancer patients, and then reinfused after being genetically engineered in the lab to attack the patient’s tumors reports weku.org . Using a drug that is living can make it last a few weeks or even a few years. This therapy offers a treatment for people that have run out of other options like stem cell therapy. Scientists are trying to make an off the shelf version of this therapy that would be available quickly, made in large quantities, and less expensive. They take T cells from a healthy donor and use CRISPR to reprogram the T cells. It reprograms it in several ways; to leave healthy cells alone, to hide from the patient’s own immune system, and to destroy cancer. While studies are showing some positive results from the off the shelf CAR T-cell therapy, it is not as effective as using the patient’s own cells. Click to read the full story.

These Tiny Bubbles are “Warheads” for Killing Cancer

These infinitesimal gas bubbles surround the tumor and then can be exploded via ultrasound, creating “therapeutic warhead,” as they artfully put it in their study, published in the journal Nanoscale freethink.com . High frequency ultrasound can damage tissues surrounding tumors. The use of low frequency ultrasound in combination with the nanobubbles reduces harm to surrounding tissues. The tiny bubbles are injected into the bloodstream which goes into the blood vessels of a tumor and is then leaked into the tissue of the tumor. The low frequency ultrasound makes the bubbles explode and that kills the cancer cells. This is an effective treatment for tumors that are located deep within the body or where there are many tumors. The hope is that this method would replace surgeries to remove cancerous tumors. The trials are currently moving from mouse trials to human trials. Click to read the full story.