What can be done for MPN patients who have failed on traditional therapies? MPN expert Dr. Claire Harrison from Guy’s and St. Thomas’ Hospital in London explains some treatments under study as options for some patients.
Dr. Nicole Rochester:
What about for patients who have failed therapies, are there any treatment strategies for MPN patients who have failed traditional therapies?
Dr. Claire Harrison:
Yes, in fact, actually, that’s where we’re evaluating new therapies across all of these entities, so if you’re a PV or an ET patient and you failed a therapy, then this is where, for example, in ET, we would be looking at bomedemstat or we’re looking at the bromodomain inhibitor pelabresib, and there’ll be other agents that we’ll be looking at, or we might be looking at vaccination. And for MF patients that while there are a bunch of different therapies for patients who you have not tolerated or progressed through standard therapy. So actually, there are a lot of options, some of them are already approved, and some of them are in clinical trials.