Chronic lymphocytic leukemia (CLL) patients can sometimes develop a second gene mutation. Watch as Dr. Nadia Khan from Fox Chase Cancer Center shares how common it is to develop a second mutation and when it’s important to retest for genetic changes.
This question comes from Laurie. How common is it for CLL patients to develop a second gene mutation?
Dr. Nadia Khan:
Laurie, Thanks for that question. It is not common for most call patients to have significant alterations in the genetic landscape of the CLL. With that being said, there are a few notable exceptions for CLL with TP53 dysfunction or complex cytogenetics, there is a higher likelihood that there will be genetic instability in those CLL clones. Therefore, it’s important to retest for changes if there is a change in the biology of the CLL, if there is a progression on therapy, for example, or at the time when a new therapy is planned.