Tag Archive for: Vitamin D

Expert Advice | Strategies for Managing MPN-Related Fatigue

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Expert Advice | Strategies for Managing MPN-Related Fatigue from Patient Empowerment Network on Vimeo.

Fatigue related to myeloproliferative neoplasms (MPNs) can be overwhelming and may have an impact on other parts of your life. So, what can be done about it? MPN specialist Dr. Naveen Pemmaraju shares advice for understanding and managing this common symptom, including lifestyle choices that may be beneficial. 

Dr. Naveen Pemmaraju is Director of the Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) Program in the Department of Leukemia at The University of Texas MD Anderson Cancer Center. Learn more about Dr. Pemmaraju. 

 

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 Understanding and Managing Common MPN Symptoms and Side Effects

Understanding and Managing Common MPN Symptoms and Side Effects

Transcript:

Katherine Banwell:

Well, it’s obvious that there’s some symptom overlap along with this.  And so I’m wondering what the strategies are for managing these. Let’s start with fatigue first.  

Dr. Pemmaraju:

Let’s do that.  

Katherine Banwell:

How do you manage that?  

Dr. Pemmaraju:

This is one of the tougher parts of what we do. I’m glad you’re pinning me down to say it, because really this is the majority of what we need to be talking about in the clinic. I’m going to just be honest, you know, with all the scientific breakthroughs and everything, some of these are limited. The fatigue, this is some of the strategies I use and some of the experts in the field. I think one is managing the underlying disease. So, as you mentioned, if you have high-risk, intermediate to high-risk myelofibrosis, one of the great findings of our field is the JAK inhibitor class generally helps to improve symptom burden.  

So, that is the splenomegaly, the fatigue, the pruritus. Maybe not so much the itching, but some of these other things. So, I think treating the underlying disease, that’s okay. Number two is many clinics, onc centers around the country are starting to open up a supportive care or fatigue center clinic. So, I am referring several of my patients there, we’re talking about diet, nutrition, exercise. We used to never talk about these things. Ruben Mesa has found that doing yoga and meditation can genuinely actually help the pathobiology to reduce the cytokine storm and improve the fatigue and quality of life. 

Dr. Angela Fleischman, our colleague at UC Irvine, has done work suggesting that possibly an antioxidant diet such as the Mediterranean diet can help the overall general fatigue, well-being, wellness. And then of course I mentioned earlier, but I’ll mention here too, sometimes fatigue is outside of the MPN. Have you had your TSH or thyroid checked? What about your vitamin D levels? How are you doing on these PCP general checks? Things that may be contributing to the life and the happiness.

And finally, let me make a plug for mental health. I don’t know how much we were emphasizing before the COVID pandemic, but after, the last three or four years have been tough. Healthcare providers, caregivers, patients themselves, mental health checkup, that can also be contributing to fatigue, not getting out of bed, in addition to the organic medical problems. So, let me advocate a multifactorial approach, scientifically summed up as treating what you can with the underlying MPN, fine, treating the side effects and symptoms of the MPN, as you said. 

And then, other, which can be a huge bucket, particularly as we get older, to not forget about that. Again, checking the thyroid level. And then when you’re on these different treatments, you can personalize it. Interferon, obviously, has its own separate set of side effects and then of course the other agents. So, I think that may be the best way to approach it. Maybe a three-bucket approach. The MPN itself, and then the treatment itself, and then the other, something like that.  

Katherine Banwell:

And as you’ve mentioned, it’s all going to be personalized and individualized.  

Dr. Pemmaraju:

Hugely.   

Katherine Banwell:

Right, because what’s going to work for one person is not necessarily going to work for another.  

Dr. Pemmaraju:

Hear, hear, well said to that. You know, you think you make a great diagnosis in the clinic, someone’s having fatigue, they’re on therapy for your MPN. You check the TSH, it’s wildly abnormal. Okay, you refer them to endocrine. Six months later, the thyroid level is completely normal now on thyroid medicine. And yet, the fatigue, brain fog, everything is still not clear.  

The MPN is under good control. What gives? That’s the difficult part of these diseases. So, I really love what you said about the personalization and to keep looking and keep trying. 

Is There a Link Between Myeloma and Dental Health?

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Is There a Link Between Myeloma and Dental Health? from Patient Empowerment Network on Vimeo.

Dr. Sikander Ailawadhi from Mayo Clinic explains that while multiple myeloma doesn’t commonly cause dental issues, there can be indirect connections via bone problems.

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Transcript:

Lisa Hatfield:

Another question from a patient since my diagnosis and bone marrow transplant, my teeth have been deteriorating, is there a connection between dental health and myeloma?

Dr. Sikander Ailawadhi:

Very important question because although this is not a very common finding, it is something that really affects quality of life, so myeloma itself does not always or frequently caused teeth problems or dentition problems, which you can imagine teeth are bones. Myeloma affects bones, Myeloma affects calcium deposition in bone so teeth can get damaged in two or three different ways in myeloma patients, first, if myeloma involves the job or you can imagine that the teeth in that particular area could become loose or they could become a little off because the structure is getting affected.

Sometimes if my novels present on the job, for example, and radiation is given, but that bone becomes weaker, so teeth can become weaker, another way myeloma and dental health can be connected is because we use certain bone-strengthening agents for myeloma. These drugs are called either bisphosphonates, for example, or zoledronic acid (Zometa) or pamidronate acid (Aredia), patients may know as Zometa or Aredia, or there’s a second category called RANK ligand inhibitors, one of the drugs there is denosumab or Xgeva, these are all drugs that are given for bone-strengthening for myeloma. Patients are recommended to take calcium and vitamin D, but a rare but definitive side effect that is known to happen or can happen with these drugs is what’s called osteonecrosis of the jaw, where basically the jaw bone is becoming necrosed or less viable.

And you can imagine if the jaw is less viable, the teeth that go into the jaw in that spot, they’ll become loose and hurt, painful…it’s not a good condition to have it very…it affects quality of life significantly. So while it is rare, this osteonecrosis of the jaw can occur maybe less than 10 percent of the cases, but it is a significant morbidity causing issue.

What I recommend to patients is that one, if that is happening, first of all, we’re not…we typically don’t continue that drug that is causing it, like a bisphosphonate or RANK ligand inhibitor. Secondly, the patient needs to see a good oral maxillofacial surgeon or a good dentist, preferably someone who has knowledge and experience in handling outreaches of the job. So different ways in which melodic treatment can affect the job, there is not a direct correlation, but in about 10 to 15 percent of cases, there may be care or death-related implications and monuments either from the disease or its treatment like radiation or bone-strengthening drugs. 

Bone-Building Therapies Recommended for Myeloma Patients

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Bone-Building Therapies Recommended for Myeloma Patients from Patient Empowerment Network on Vimeo.

What can multiple myeloma patients do for bone-building therapies? Dr. Sikander Ailawadhi from the Mayo Clinic discusses bone-strengthening drugs and some physical activities to help with bone care.

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Transcript:

Lisa Hatfield: 

So if a patient cannot take bisphosphates doesn’t explain the reason why, are there other bone-building therapies that are recommended to protect them?

Dr. Sikander Ailawadhi: 

Sure, so I would say that while we talk about these drugs like bisphosphonates, RANK ligand inhibitors, there are some other drugs that can be used to strengthen the bones, because you can imagine these molesting agents are used in a lot of different cancer, breast cancer, prostate cancer, etcetera. So this family of drugs can be used, there are some that are used less frequently, but can be used instead of bisphosphonates and denosumab (Prolia), but I would bring the patients back to even more basic stuff, calcium, vitamin D, exercise, bone-strengthening exercise. These are the first steps.

Then come the other bone-modifying drugs, so even if a patient has been told that they cannot get any of those drugs because of the side effects, they could certainly say calcium, vitamin D after discussing with their doctors, and they can regularly do some bone-strengthening building exercises sometimes it’s as simple as swimming, as simple as spinning, but those are like on the stationary bike, but those are extremely important activities to help build bone mass. 

Lisa Hatfield:

All right, thank you. Have you ever had a patient that has reached complete response that you said, Well, maybe you don’t need to continue on bisphosphonates, that ever an option for patients to not continue after a certain period of time?

Dr. Sikander Ailawadhi:

Again, excellent question. And, in fact, historically, all the bisphosphonate-related clinical trials had up to a two-year follow-up, so a lot of times we used to say, “Well, at two years we need to stop them because there’s no safety data beyond that.” But more recently, there are studies that have shown that even every three months of bisphosphonates is as good as every month. So if somebody has active bone-affecting myeloma, then their treatment can be given every month or every three months.

But if a person has gone into remission, and remember, the myeloma was the exciting event that was causing the bone loss, if there is no disease, if there are no active ones and the person is in good health, they are active…no bone-related issues. You’ve done imaging. Everything is good. I think it certainly it can be done that bisphosphonate can be stopped. And, of course, this needs to be actively discussed with the patient, frankly, other than having the side effect concern, if I can have a patient not coming for the treatment and they can spend that much extra time with their family doing what they want to…I think that’s a win-win. 

Benefits of Vitamins

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Benefits of Vitamins from Patient Empowerment Network on Vimeo.

Vitamins are very important compounds that are required in small amounts in the diet to support various functions related to growth, reproduction, and the maintenance of health. Watch now.

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Transcript:

Vitamins are essential micronutrients that are required for many bodily functions and therefore necessary to maintain health. Vitamins are traditionally categorized into two groups: water-soluble meaning they are dissolvable in water or fat-soluble meaning they are dissolvable in fat. 

Water soluble vitamins include a collection of B vitamins and vitamin C. Vitamin C is a powerful antioxidant found in citrus fruits like oranges and grapefruit and in cruciferous vegetables like broccoli and Brussels sprouts. The collection of B vitamins all assists in various metabolic processes in the body and are found in a variety of unprocessed plant-based foods and animal foods. Vitamin B12 is mainly found in animal foods but can be easily obtained through fortified cereals and non-dairy milks for those consuming a plant-based diet.

Fat soluble vitamins include Vitamins A, D, E and K. Vitamin A is an antioxidant and supports eye health found in leafy green vegetables like kale, orange and yellow vegetables like carrots. Vitamin D supports bone health and is obtained through exposing the skin to the sun, eating fatty fish and fortified foods. Vitamin E is an antioxidant that protects cell membranes and is found in nuts, seeds, fruits, and vegetables. Vitamin K supports blood clotting and bone health and is found in green leafy vegetables and Brussels sprouts.

Unless there is a deficiency, it is recommended to primarily focus on getting vitamins from food sources vs supplementation. By eating a variety of whole foods from all food groups, you can ensure that you are getting all the vitamins needed to maintain health, protect against cancer and support recovery from cancer treatment.

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