Diagnosing Diffuse Large B-Cell Lymphoma (DLBCL) typically begins with a physical exam, a review of your medical history, a biopsy, and blood tests to confirm the diagnosis and assess disease progression.
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Providers typically use the Ann Arbor staging system. Staging lymphoma differs slightly from solid tumors because it is a blood cancer involving the lymphatic system. Staging is based on the number and location of affected lymph nodes. The stages include:
- Stage I: Involvement of a single lymph node region
- Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm
- Stage III: Involvement of lymph node regions on both sides of the diaphragm
- Stage IV: Involvement of one or more organs (e.g., bone marrow, liver, kidney, or lungs) outside the lymphatic system
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- ABC (Activated B-cell-like): Can be classified as high-risk or low-risk
- Double-hit or triple-hit lymphoma: Also referred to as high-grade B-cell lymphoma
- GCB (Germinal Center B-cell-like): Can also be high-risk or low-risk
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What Are the Subtypes of DLBCL?
Understanding Diffuse Large B-Cell Lymphoma (DLBCL) and Its Subtypes
A biopsy—typically involving removal of part or all of a lymph node—is required for a definitive diagnosis. The following tests are commonly performed on the biopsy sample:
- Immunohistochemistry staining: Identifies cancerous cells by staining surface or internal markers.
- Flow cytometry: Classifies cells (B-cell or T-cell clones) and helps differentiate lymphoma types.
- Biomarker Testing: Detects genetic mutations and classifies lymphoma into risk groups.
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Tools to help you feel activated and connect with resources to overcome barriers to accessing care.
Topics:
- Understanding Diffuse Large B-Cell Lymphoma (DLBCL)
- DLBCL Treatment Options and Advances
- DLBCL Patient Support and Care
- DLBCL Patient Profiles
- [ACT]IVATED DLBCL Resources
Provides actionable advice and downloadable materials to help you communicate clearly and effectively with your DLBCL healthcare team.
Topics:
- Understanding DLBCL
- DLBCL Treatment Approaches
- Tips for DLBCL Patient Self-Advocacy
- Planning Your DLBCL Doctor’s Office Visit
- Pro-Active DLBCL Patient Resources
