How Is Small Cell Lung Cancer (SCLC) Diagnosed?
Diagnosing small cell lung cancer (SCLC) starts with a physical exam and an assessment of symptoms. Diagnostic tests—including imaging scans, biopsies, and molecular testing—confirm the presence of SCLC and help determine its subtype.
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Small Cell Lung Cancer Staging and Subtypes
SCLC is typically divided into two stages:
- Limited-Stage SCLC: Cancer is confined to one lung and may have spread to nearby lymph nodes.
- Extensive-Stage SCLC: Cancer has spread beyond one lung to the opposite lung, distant lymph nodes, or other organs.
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Essential Small Cell Lung Cancer Testing
Testing is crucial for identifying the SCLC subtype, evaluating the stage, detecting genetic mutations, guiding treatment decisions, and monitoring response to therapy.
Testing Methods in SCLC
- Imaging Tests: X-rays, CT scans, PET scans, and MRIs to detect tumors and assess spread
- Biopsy: Tissue sample collection through bronchoscopy, needle biopsy, or surgical biopsy to confirm an SCLC diagnosis
- Cytology Tests: Examination of sputum or lung fluid to detect cancer cells
- Biomarker Testing: Identifies specific genetic mutations and protein expressions to personalize treatment
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SCLC Biomarkers
- TP53 Mutation: Found in nearly all SCLC cases, plays a role in tumor suppression
- RB1 Mutation: A key tumor-suppressor gene mutation in most SCLC cases
- MYC Amplifications: Linked to more aggressive SCLC subtypes
- DLL3 Expression: A potential target for emerging therapies
Small Cell Lung Cancer Diagnosis & Testing Programs
Tools to help you feel activated and connect with resources to overcome barriers to accessing care.
Topics:
- Small Cell Lung Cancer Patient Profiles
- Managing Small Cell Lung Cancer Care
- Small Cell Lung Cancer Treatment and Clinical Trials
- [ACT]IVATED Small Cell Lung Cancer Resources
Provides the knowledge to actively participate in care decisions and understand support resources available.
Topics:
- Understanding Small Cell Lung Cancer Care and Treatment
- ELEVATE Small Cell Lung Cancer Resource Guide
