Understanding treatment options, goals, and what to expect is essential to achieving the best possible outcome in Diffuse Large B-Cell Lymphoma (DLBCL).
- Gather information
- Find a team you trust
- Write down your questions
- Understand the complete treatment plan, including its intent and potential side effects.
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- What is my diagnosis?
- What is the stage of my disease?
- Is my disease low or high risk?
- Is there a potential for a cure?
- What treatment options are available to me, including clinical trials?
Treatment approaches for DLBCL depend on factors such as disease stage and location, the patient’s overall health and age, laboratory and biomarker results, and possible side effects. Common treatment types include:
- R-CHOP: A five-drug regimen, given once every three weeks for up to six cycles. Includes rituximab, cyclophosphamide, doxorubicin hydrochloride, vincristine sulfate, and prednisone.
- Pola-R-CHP: Uses polatuzumab in lieu of vincristine, which is part of the R-CHOP regimen.
- This was tested against R-CHOP and showed improvement by about 5%-6% in terms of long-term remission.
- Dose-adjusted EPOCH: A chemotherapy regimen sometimes used before or alongside CAR T-cell therapy.
- CAR T-Cell Therapy: Targets CD19 or both CD19 and CD20. This therapy is often used in clinical trials for patients who relapse within the first 12 months of initial treatment.
- Bispecific Antibodies: Engineered to bind to two different antigens by combining regions from two different antibodies.
- Stem Cell Transplantation: Particularly beneficial for patients who relapse more than 12 months after their initial treatment.
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DLBCL Treatment and Research Updates Patients Should Know About
DLBCL Treatment Approaches for Newly Diagnosed and Relapsed/Refractory Patients
Tools to help you feel activated and connect with resources to overcome barriers to accessing care.
Topics:
- Understanding Diffuse Large B-Cell Lymphoma (DLBCL)
- DLBCL Treatment Options and Advances
- DLBCL Patient Support and Care
- DLBCL Patient Profiles
- [ACT]IVATED DLBCL Resources
Provides actionable advice and downloadable materials to help you communicate clearly and effectively with your DLBCL healthcare team.
Topics:
- Understanding DLBCL
- DLBCL Treatment Approaches
- Tips for DLBCL Patient Self-Advocacy
- Planning Your DLBCL Doctor’s Office Visit
- Pro-Active DLBCL Patient Resources
Provides tools and resources for living with and beyond DLBCL.
Topics:
- Collaborating On Your DLBCL Care
- Understanding DLBCL Treatment Options
- THRIVE DLBCL Resources
