Tag Archive for: non-melanoma skin cancer clinical trials

Advice for Accessing Advanced Non-Melanoma Skin Cancer Clinical Trials

Advice for Accessing Advanced Non-Melanoma Skin Cancer Clinical Trials from Patient Empowerment Network on Vimeo.

Participating in advanced non-melanoma skin cancer clinical trials may feel overwhelming for some patients. Dr. Soo Park discusses how clinical trials fit into patient care and shares advice for overcoming obstacles to accessing cutting edge therapies.

Dr. Soo Park is a Medical Oncologist at Moores Cancer Center at UC San Diego Health. Learn more about Dr. Park.

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Non-Melanoma Skin Cancer Staging | What Patients Should Know

Non-Melanoma Skin Cancer Staging | What Patients Should Know

Advanced Non-Melanoma Skin Cancer | Establishing a Treatment Plan

Advanced Non-Melanoma Skin Cancer | Establishing a Treatment Plan

An Expert’s Perspective on Advanced Non-Melanoma Skin Cancer Research

An Expert’s Perspective on Advanced Non-Melanoma Skin Cancer Research


Transcript:

Katherine:

Beyond what has been approved to treat advanced non-melanoma skin cancer, where do clinical trials fit in?  

Dr. Park:

Clinical trials are great, because they’re the reason why we have the drugs that we have today that are working so effectively. And so, I’m really fortunate to be at a center where we offer clinical trials for patients.  

Clinical trials always fit in at any point in the journey, as long as they fit your disease. So, most of the clinical trials we have are for patients that have advanced disease, not for early stage, because the early stage patients don’t really need it; because with just simple surgery, they tend to do really well, and their cancer doesn’t really ever come back and cause issues.  

But clinical trials are really important, because they’re the only way we can study a promising treatment option; see how well it works, and if it works really well, then move it further on to hopefully help a lot of other people. And that’s why we have immunotherapy today – is through clinical trials; and immunotherapy is used for lots of cancers.  

Katherine:

Are there barriers to accessing trials? And if so, do you have any recommendations on how to tackle them?  

Dr. Park:

Yeah, there are barriers to trials, and I think the thing that the cancer community is really trying to work on is barriers to accessing trials if you’re from an underrepresented population in medicine. So, based on your socioeconomic status, meaning how much money do you make or what your education level is, what race are you, what ethnicity, what is your background; because we know that there’s a disparity for those individuals. And so, I think really asking your doctor, staying curious; asking them, “Could a clinical trial help me?” 

Even if you have no idea of really what trials there are, or what they really mean, you can just throw that word out; and that then, the doctor knows that you’re potentially interested, and they can actually give you the information and help you learn more about it, even if you don’t know much about it; because I think it’s still quite a black box, and we’re trying to overcome this barrier, but it’s difficult.  

Katherine:

And what about researching clinical trials online? What sites would you recommend?  

Dr. Park:

So, I have to admit that there are multiple sites, but sometimes they are not very patient-friendly. Even whenever I look at them, they are not very friendly. I think the largest repository of clinical trials is the NCI database. It’s just where every clinical trial that’s open has to be registered, and it’s run by the federal government, I believe. And because it’s not super regulated, it’s just the person working on the trial entering information, and they’re typically of a medical background, sometimes the information is not very easy to digest or understand.  

So, I think really just letting your medical team know that you might be interested in a trial, then they can help you find the right trial for you. And if they don’t have one, they can tell you other areas or other centers that might have one. You are more than welcome to go search in Google and all that, but it can be really hard, and then I don’t want that to make the patient feel that this is not for them.  

Non-Melanoma Skin Cancers and Clinical Trials | Advancing Science for Everyone

Non-Melanoma Skin Cancers and Clinical Trials: Advancing Science for Everyone from Patient Empowerment Network on Vimeo.

What is the value of non-melanoma skin cancer clinical trials? Expert Dr. Silvina Pugliese from explains why clinical trial participation is important and shares advice for patients.

Silvina Pugliese, M.D., is a Clinical Assistant Professor of Dermatology and Attending Physician at the Stanford Medicine Outpatient Center and Stanford Cancer Institute. Learn more about Dr. Pugliese.

[ACT]IVATION TIP

“…if you are interested in participating in a clinical trial, in advancing medical knowledge, and you feel comfortable doing so, please ask your dermatologist or your oncologist, whether they’re aware of any clinical trials that are available for your particular type of skin cancer.”

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See More from [ACT]IVATED Non-Melanoma Skin Cancer

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An Oncodermatologist Shares Treatment Updates for Basal and Squamous Cell Skin Cancers

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What Should Non-Melanoma Skin Cancer Patients Consider About Treatment?

What Should Non-Melanoma Skin Cancer Patients Consider About Treatment?

Hopeful Outcomes In Immunotherapy for Non-Melanoma Skin Cancers

What Is the Role of Immunotherapy for Non-Melanoma Skin Cancers?


Transcript:

Mary Leer:

Why is clinical trial participation so important in non-melanoma skin cancers, and what advice do you have for patients considering a clinical trial?

Dr. Silvina Pugliese:

This is a great question. So it is much more common to have early stage localized disease for basal cell cancer and squamous cell cancer. So the overall case number that we see for advanced or unresectable or metastatic disease for squamous cell cancer and especially for basal cell cancer is much lower than the usual numbers we hear of 4 million cases annually of basal cell cancer in the U.S., and 2 million of squamous cell cancer. And the reason this is important is because when we have a lower pool to evaluate or study, when we think about these more advanced skin cancers, we have less patients to recruit for some of these studies. This is especially important when we think about advanced or metastatic basal cell cancer, which is very rare.

Also very important we think about less common skin cancers like Merkel cell carcinoma or DFSP. And when we think about how uncommon these skin cancers can be in skin of color, we realize we’re really drawing from a very small pool of patients. So my point here is that you can make a true impact by enrolling in a clinical trial, especially as we’re looking at what are some of the best treatment options for these more advanced skin cancers or metastatic skin cancers? Because we do need the right patients to be enrolled in order to study these research questions.

So my activation tip is, if you are interested in participating in a clinical trial, in advancing medical knowledge, and you feel comfortable doing so, please ask your dermatologist or your oncologist, whether they’re aware of any clinical trials that are available for your particular type of skin cancer. Of course, never feel any pressure to do this, it’s completely optional, but often it can provide more, a novel treatment option for your cancer or allow you to have certain treatment that’s not available through insurance, for example, at the moment. And also in doing so, advance the knowledge that we have in our field and help patients in the future who have your same skin cancer and are in your same position. 


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