Should Families of Renal Medullary Carcinoma Patients Undergo Genetic Testing?
Should Families of Renal Medullary Carcinoma Patients Undergo Genetic Testing? from Patient Empowerment Network on Vimeo.
Does renal medullary carcinoma (RMC) warrant genetic testing for any relatives of patients? Expert Dr. Nizar Tannir explains the frequency of RMC in siblings and shares advice for blood relatives of RMC patients.
Dr. Nizar Tannir is a Professor in the Department of Genitourinary Medical Oncology, Division of Cancer Medicine at The University of Texas MD Anderson Cancer Center.
“…please do not panic. Hopefully, you will live a normal life, and you will not have RMC, but you should be diligent.”
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Dr. Tannir, newly diagnosed RMC patients may be worried about their family members getting RMC as well. Is this something that patients and their families need to be worried about?
I don’t think so, Cora. I tell you I get this question asked by patients and their families, because you know that again we said that the cardinal finding in RMC is the individual has sickle cell trait and they got the sickle cell trait from one of the parents, or both parents have sickle cell trait or one of them do. So, and there may be other siblings to that individual to that subject patient with RMC who has sickle cell trait. I don’t think having a sibling or a child with RMC if the other family members, first-degree, blood relatives should be equated with RMC. So my activation tip here is do not panic, you know just because your brother or sister has RMC and they have sickle cell trait and you may have sickle cell trait, that you are not necessarily going to get it.
In fact, I’ll be honest with you, I have not seen two family members with RMC, I have not seen it. I mean not that it will never happen or had not happened, could have happened, I’m sure, but it is so rare that I think one should not equate if my brother, my sister has and I have sickle cell trait, I’m going to get it too. There is a lot we do not know about why that sibling with sickle cell trait got it. And I who has sickle cell trait didn’t get it. You know that’s what we’re trying to understand and the knowledge that we need to acquire to really get to the bottom of it. But my activation tip for this is, please do not panic. Hopefully, you will live a normal life, and you will not have RMC, but you should be diligent.